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Common signs include fatigue, brain fog, numbness or tingling, irritability, and shortness of breath

These products include: Retatrutide Reta R-10, R-20 Investigations are ongoing

Biomarkers correlating the lower IGF-1 concentration to increased waist-to-hip ratio or to impaired glucose tolerance are also being studied [224, 225]

These agents are FDA-approved primarily for the management of type 2 diabetes mellitus and, for specific products (Wegovy, Saxenda, Zepbound), for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity

Treating a deficiency can help remove these barriers