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Increasing dietary intake of creatine enhances its concentrations in plasma and tissues, such as skeletal muscle, brain and heart (Derave et al

The ATP-grasp fold is conserved within the ATP-grasp superfamily and is characterized by two alpha helices and beta sheets that hold onto the ATP molecule between them

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When GPx3 was correlated to age, we also found a poor correlation exists between these two variables (Pearson correlation coefficient (r) = 0.17, p = 0.02), indicating that age is not strongly influencing the differences of GPx3 abundance in this sibling cohort (Supplementary Fig

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