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In AD, impaired function of AQP4 disrupts A clearance

43 It should also be noted that although GSH inhibits the production of most inflammatory cytokines, it is required to maintain an adequate interferon-gamma (IFN-gamma) production by dendritic cells, 44 which is essential for the host defense against intracellular pathogens such as mycobacteria

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ROS are essential for activation of NF-B and IRF-3 signaling induced by HSV infection The signaling pathways upstream of the transcription factors NF-B and IRF-3 are important for establishment of innate antiviral defense against HSV [1], [2]

Proc Natl Acad Sci USA 1996, 93: 94939498