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Even though most of the SP are still under investigation, some of them have been studied in vitro and in vivo with promising results that may lead to preclinical studies

The principle of superposition assumes that early doses of drug do not affect the pharmacokinetics of subsequent doses

Investigations of the Pseudomonas ketosteroid isomerase based on deuterium and tritium labeling of reactants provided evidence for direct and stereospecific diaxial proton transfer from the 4 to the 6 position (Talalay, 1965)

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