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Meanwhile, NNMTi treatment significantly increased energy expenditure in mice, an effect closely related to elevated NAD levels following NNMT inhibition

Effects of AOD-9604 on adipose tissue and metabolic function: A clinical review

The implication for clinical practice is that restoring youthful MOTS-c signaling might be a mechanistically legitimate target for longevity intervention

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For wellness-focused clients without confirmed deficiency, many practitioners offer monthly injections, though this should be supported by appropriate assessment and documentation