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What the Research Shows In the STEP 1 clinical trial, published in Diabetes, Obesity and Metabolism (Wiley), participants receiving semaglutide 2.4 mg once weekly achieved an average weight loss of 17.3% over 68 weeks, compared with 2.0% in the placebo group

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GLP-1 medications, specifically semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), work in part by acting on receptors in the brain that regulate hunger