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Use typically relates to experimental or off-label contexts rather than approved medical treatment

Supraphysiological testosterone concentrations have been shown to reduce endothelial nitric oxide synthase expression and nitric oxide bioavailability, thereby favouring vasoconstriction and increased arterial stiffness ( Oxidative stress appears to represent a central mechanistic pathway linking molecular signalling alterations with structural cardiac pathology

Plant Physiol 142(4):13641379