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These include the use of the peak area normalized to the internal standards ( Despite the impact that normalization may have in correcting the noise from external variating factors, most reviewed results did not include a normalization step in their data processing pipeline ( 4 Identification of biomarkers and metabolic pathways in drug hepatotoxicity assessment Several metabolites emerge as biomarkers of hepatocyte injury from metabolomic studies on hepatotoxicity and are gathered in Supplementary Table S3