This trend is associated with substantial increases in morbidity and mortality, driven by complications including type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disease
However, the FDA has issued a strong warning: certain bulk drug substances used in compounding may carry serious safety risks and, in some cases, may violate federal law
For acute injuries, split dosing (half the daily amount every 12 hours) maintains more consistent tissue levels
DOI: 10.1016/S0169-409X(96)00423-1 Llompart, P
Factors such as cost savings, convenience, absorption issues, potential digestion, and comfort with self-administering injections can affect patients preferences