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The peptide was originally characterized by the Sikiric group at the University of Zagreb School of Medicine and has been investigated for over two decades in preclinical research models for its effects on tissue regeneration, angiogenesis, fibroblast migration, and cellular signaling across tendon, ligament, muscle, gastrointestinal, and vascular tissues
The peptide tells cells what to do
When tissues or organs are damaged, it is released from damaged cells into the extracellular space or directly as a component of necrotic cell debris
Thus, the functions of the redox system are multifaceted, which underscore the necessary co-existence of NOX activation and enhancement of glutathione pool acquired as two important survival and proliferation features in cancers