In the primary murine peritoneal macrophages used in this study, constitutive glutathionylation of endogenous IRF-3 was not detected (data not shown), but our data do not exclude that ROS enhance signaling at the level of IKK and MAVS
\n\n\n\n These findings have generated genuine scientific interest in BPC-157 as a potential candidate for further development in IBD research, though the absence of human clinical trials means that clinical applicability remains to be established
Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1083 - ESOC25-2127 THROMBOEMBOLIC STROKE ALTERS CLAUDIN-5 ISOFORM EXPRESSION CORRELATING TO INCREASED CEREBRAL INFARCT AND EDEMA AS WELL AS DECREASED NEUROLOGICAL FUNCTION Trevor Wendt 1 , Kajsa Arkelius 1 , Henrik Andersson 1 , Rayna Gonzales 2 , Saema Ansar 1 1 Lund University, Lund, Sweden, 2 University of Arizona College of Medicine - Phoenix, Phoenix, United States Background and Aims: Claudin-5, coined as the gatekeeper of neurological function, is integral in the maintenance of the blood-brain barrier (BBB)
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