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doi: 10.3389/fimmu.2025.1619835 Received 28 April 2025 Accepted 03 June 2025 Published 19 June 2025 Volume 16 - 2025 Edited by Marcin Okrj, Medical University of Gdask, Poland Reviewed by Andrea Balduit, Institute for Maternal and Child Health Burlo Garofolo (IRCCS), Italy Daniel Ajona, University of Navarra, Spain Updates Copyright 2025 Alarabi, Alshbool and Khasawneh

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But he does employ the venerated concepts of the Four Elements (the Aristotelian Fire, Earth, Air, and Water) and the Four Qualities (the Hot, the Wet, the Cold, and the Dry) to propound how compounds drugs could be mixed and how simples could work against diseases characterized by any one of the Qualities