5.1.1 Drought stress Drought is one of the most significant challenges for agriculture ( Amaranthus uses physiological strategies such as reduced transpiration, increased water-use efficiency (WUE), osmotic adjustment via proline and raffinose oligosaccharides, and antioxidant accumulation ( A
Similar mechanisms may be responsible for the enhanced vasodilatory action of peroxynitrite (ONOO) in the presence of GSH: peroxynitrite reacts with GSH to form S-nitrosothiols (RSNOs), which subsequently release NO over a prolonged period of time, thus extending NO's half-life and, as a result, relaxing vascular tone (25)
The molecular details of how mitochondrial ROS regulate these diverse biological outcomes are currently being intensely investigated
Deleting the GPX4 gene or treatment with GPX4 inhibitors (e.g., RSL3, ML162, and ML210) induces lipid peroxidation and concomitant ferroptotic cell death in T cells in vitro (Matsushita et al., 2015
Cancer Lett 194:5566