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By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models

Antioxidant capacity values were 39.8 and 93.7 mol TE/g of sample for black cumin and black sesame extracts (Table 6)

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Side Effects and Safety Profile Reported side effects at standard 250-500 mcg dosing are mild and infrequent: injection site redness, mild fatigue, headache, and occasional nausea at higher oral doses