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However, a more localized synaptic expression of MET in the adult brain was indeed shown (Eagleson et al., 2013)

Accordingly, Weiss and coworkers performed a series of experiments to examine the effect of selenium administration (single intraperitoneal injection) through sodium selenite (1.6 mg/kg body weight) or SeM (0.8 to 4 mg/kg body weight) on improving the 30-day survival of mice against lethal doses (910 Gy) of whole body -irradiation (WBI) (Table 2) [42,43,44]

This route loses 6075% of active peptide to hepatic first-pass metabolism and renal clearance before any meaningful dermal concentration is achieved

On the other hand, there are groups that should avoid peptide therapy altogether

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