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The Khavinson bioregulatory model proposes that the Lys-Glu-Asp sequence penetrates cell membranes and interacts with DNA in promoter regions of vascular-expressed genes

Animal plausibility is not human proof

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Many patients have undiagnosed low b12 even before medication use, particularly among certain risk groups

Interventions aimed at reducing cellular O-GlcNAcylation have been shown to facilitate the induction of the p75 neurotrophin receptor (p75NTR) by hypo-osmolarity, thereby establishing a direct link between protein O-GlcNAcylation, p75NTR induction, and hyperosmotic stress [108]