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These types of e-liquids with or without nicotine also demonstrated cytotoxic and genotoxic effects on human oropharyngeal mucosa 65 and showed varied effects on epithelial cell proliferation and viability that extended beyond the constituents of nicotine and propylene glycol/vegetable glycerin in the e-liquid fluids 66

Many rodent models exploring the effects of nicotine in pancreatic disease have been developed

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