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Update 08 January 2026 : Datopotamab deruxtecan received an additional approval for use in EGFR-mutated NSCLC later in 2025

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Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells

It interacts with multiple systems in the body including the nitric oxide (NO) pathway, growth hormone receptors, and angiogenic regulators like VEGF (vascular endothelial growth factor) to promote tissue repair, reduce oxidative stress, and modulate the immune response