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So, by silencing the circuit, we were able to demonstrate for certain that this was a very important neural encoder of the behavioral aspect of high-dose nicotine. The only drug designed to help with nicotine cessation, varenicline, could work by increasing aversion via the alpha-7 receptor and lessening desensitization of the alpha-4/beta-2 receptor, she said, but its precise mechanism of action is currently unknown

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"She put up with his smoking at first because its his only vice left and she didnt want to be a nag, but she cant stand it." They added, "She hates cigarette smoke, and whats worse, shes smelling it on his clothes