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Recently, biomimetic delivery systems, particularly cell-based carriers, have garnered increasing attention owing to their remarkable biosafety, immune compatibility, and self-driven migration towards disease lesions 39,40,41,42,43

This may be the most practical approach for people using 10 mg/mL concentration who want to avoid the extremely small volumes that once-weekly microdosing requires

Interestingly, in subjects with the highest systolic blood pressure at baseline of 150 mmHg, Pycnogenol supplementation had the greatest relative normalization effect with a reduction to 134 mmHg, which translates to a reduction of 11% compared to baseline