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Next, water molecules and small molecule ligands were removed from the protein, hydrogen was added, and the active pockets in the 3D structure of the protein were identified by AutoDock Tools

35, 36 Mice were weighed twice weekly to assess toxicity and killed when tumors reached 1500 mm 3 or they experienced any severe morbidity (that is, body weight 2, (b) a significant difference ( P 60% were considered to have low activity