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This pruning process occurs earlier in the auditory and visual cortex (by approximately 12 years of age), than in areas of the prefrontal cortex, which plays a role in executive functions such as problem solving and decision making (by approximately 18 years of age) (Bourgeois et al., 1994

Hemorrhoids and fissures share overlapping pathology, but extrapolating from fissure data to hemorrhoids is mechanistically plausible, not clinically validated