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however, human PK studies were submitted and are more informative ( 4 Discussion and next steps For ethical and scientific reasons, there is a need to use reproducible and human-relevant testing approaches without the use of animals to better understand the potential adverse effects of TNCPs on humans

To be sure, the FDA has made progress in a mammoth task: processing nearly 26 million product applications submitted by manufacturers hoping to enter or stay on the market

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All of us at PMI are determined to replace cigarettes with smoke-free alternatives that combine sophisticated technology and intensive scientific validation, he said