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This finding is opposite from conventional oral squamous cell carcinoma where the female to male ratio is 1:3

Assessed neuropsychiatric features were delayed motor development, clumsiness, chronic fatigue, headache/migraine, impaired memory and concentration, paresthesia, cardiovascular dysautonomia, sleep disturbances, anxiety/panic/fears, allodynia, depression, and neuropathic pain

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Interestingly, under in vitro conditions, smokeless tobacco aqueous extracts and TSNAs demonstrated either a reduction of growth for Fusobacterium nucleatum or no change in profile