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Consuming too much of this essential vitamin may come with side effects, which range from minor digestive issues to more serious health issues

PMID 20021721

As the residue identity between MPGES1 and MGST1 is partly high for the TM1-TM2 loop (in this cytoplasmic loop, 5 out of 8 residues among K42-D49 are conserved between MGST1 and MPGES1), it may be the case also for MGST1 that this loop is not directly involved in GSH binding but serves other purposes

doi: 10.1016/j.cell.2017.02.004 127 KimYCGuanK-L

In these situations, the goal is usually to support mobility, maintain tissue stability, and promote consistent recovery during periods of increased physical stress