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While generally less harmful than smoking combustible tobacco, they carry risks like nicotine addiction, lung inflammation, and exposure to metals from the heating element

Therefore, this study is noteworthy in subgroup analysis by calculating pack-years and smoking behavior, such as dual smoking

Free Radic Biol Med (2002) 33(6):84756

The ability to change with fluctuating dopamine levels makes the DRD3 receptor critical in dopamine-related functions and cognition.[ref] DRD4 receptor: This dopamine receptor is found at lower levels than DRD1 through DRD3