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It consists of three categories: [39] Category 1A: Carcinogenic Category 1B: May cause cancer Category 2: Suspected of causing cancer The former European Union classification of carcinogens was contained in the Dangerous Substances Directive and the Dangerous Preparations Directive

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It is, therefore, conceivable that the carcinogens taken within ETS can also cause OSCC in NSND, for which the mechanisms of formation with different lifestyle factors are still largely unknown, and furthermore, the carcinogens can increase the risk of OSCC in active smokers 15,28

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