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The activation of monocytes participates in the formation of PAD ( Aryl hydrocarbon receptor (AHR) is a member of the transcriptional regulator bHLH (basic helix-loop-helix)-PAS (Per-ARNT-Sim) family, which mainly regulates various developmental and physiological functions ( Monocytes and macrophages that enter the endothelium release large amounts of MPO that forms hypochlorous acid (HOCl) and hypothiocyanic acid (HOSCN)

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Besides this, some other factors can impact the number of puffs directly

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