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FIN56 was discovered through the modulation map of 56 caspase-independent lethal compounds

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doi: 10.1007/s12020-019-01982-1 124 CarottiSGuarinoMPLValentiniFPorzioSVespasiani-GentilucciUPerroneGet al

Additionally, using TSQ fluorescence, evidence for intracellular zinc-accumulation was found within the CA1 pyramidal neurons but not before 24 h post-ischemia, suggesting that the release of zinc from synaptic vesicle stores is neither excessive nor immediately accumulated in vulnerable post-synaptic neurons

Conversely, LMW-HA fragments generated by hyaluronidase-mediated degradation at the wound interface play a stimulatory role by activating endothelial cells and fibroblasts, thereby facilitating angiogenesis, cellular proliferation, and granulation tissue formation [8]