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Similar content being viewed by others Introduction Melasma affects photoexposed areas, especially in women of reproductive age, but no curative treatment is available, significantly impacting the quality of life, including low self-esteem that leads to social contingencies, anxiety, and depressive symptoms [1,2,3]

However, supplementation with sodium selenite (1000 g per 2 h) increased MDA levels significantly by the fifth day of treatment, [31] which may be related to pro-oxidant effects of Se at high doses

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