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Besides ATF4, another transcription factor that regulates xCT expression is the nuclear factor erythroid 2-related factor 2 (NRF2) via the antioxidant response element (ARE) present in the promoter region of xCT gene (40, 41)

The mechanisms of the progressive degeneration of RGCs and their axons in glaucoma have been attributed to various factors, such as the elevation of IOP, the activation of immune cells, altered trabecular meshwork (TM) cells, and dysregulated gut microbiota

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PMID: 39653978 BMC Immunol CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis