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Restoring adequate B12 levels in deficient individuals can improve energy levels and overall wellbeing, potentially making it easier to adhere to a structured weight loss programme involving dietary modification and exercise

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In a recent investigation undertaken by our group, adult mice with partial IGF-1 showed a decrease in the expression of genes involved in glucose metabolism (phosphoenolpyruvate carboxylase-1, glucose-6-phosphatase, pyruvate dehydrogenase kinase isoenzyme-4, and ATP-citrate lyase), resulting serious hyperglycaemia [164]