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Keywords: GPCR, GRK, second messenger-dependent protein kinase, PKC, PKA, desensitization, functional selectivity, MOPr GPCR desensitization: the classical model The desensitization of a G protein-coupled receptor (GPCR) response can be described as the loss of response subsequent to prolonged or repeated administration of an agonist (Hausdorff et al ., 1990)

3 In addition to disrupting calcium metabolism, lead can mimic and displace magnesium and iron from certain enzymes that construct the building blocks of DNA (nucleotides) and disrupt the activity of zinc in the synthesis of heme (the carrier of oxygen in red blood cells)

Injectable and photopolymerizable tissue-engineered auricular cartilage using poly(ethylene glycol) dimethacrylate copolymer hydrogels