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Diverse Sesquiterpenoids from the Roots of Croton crassifolius and Their Inhibitory Effects on Ferroptosis

Mechanistically, as primary substrates of PUFAs, arachidonic acid (AA) and adrenic acid (AdA) in their free state are catalyzed by acyl-CoA synthase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) to form PL-PUFA complexes

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Upadhyay et al ., showed that ibuprofen induced proteasome dysfunction, mitochondrial-mediated apoptosis, and cell death in A549 and/or Cos-7 cells 38

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