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Dysfunction of the dopamine system is one of the most significant risk factors for addiction, according to a 2009 article by Dreher et al., published in the journal PNAS , titled Variation in dopamine genes influences responsivity of the human reward system. Drug addiction is an archetypal gene by environment disorder, as noted in a 2019 article by Lisa R

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This suggests that continued use of the medication may be necessary to sustain abstinence or maybe that other relapse prevention skills need to be taught while actively taking the medication that can help youth stay abstinent after stopping the medication

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