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Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision

Extended continuous use can reduce receptor sensitivity and potentially cause copper accumulation concerns

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A few years after California began investigating Empower, FDA investigators in 2022 found that the company had distributed batches of Lipo-B injectables which help with weight loss despite making the drug with vitamins labeled by the manufacturer as not for drug use, records show

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