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found that Lipoxin A4 could increase GPX4 levels by activating the ESR2/LPAR3/Nrf2 axis, inhibit FLS ferroptosis, thereby reducing synovial inflammation, alleviating cartilage degeneration, and mitigating pain and pathological progression in knee OA (Hu et al., 2024)

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Similarly, sibutramine (Meridia), a serotonin and dopamine reuptake inhibitor that works by inducing satiety and increasing energy expenditure 8 , was approved in 1997 against a background of divided opinion on its safety profile because, while effective for weight-loss, it tended to increase blood pressure and pulse rate 6