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The chemicals found in cigarette smoke, such as nicotine and carbon monoxide, can greatly Bone, joint, and muscle problems According to the American Academy of Orthopedic Surgeons, smoking can harm the health of bones, joints, and muscles, resulting in poorer outcomes from orthopedic surgery

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38, e387123 (2023), Abstract HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling: Pedrazza, L., Martinez-Martinez, A., et al