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In 2006 a federal court, finding that the industry had caused "an immeasurable amount of suffering," ordered it stop labeling cigarettes with designations such as low tar, light and natural that gave the misleading impression that they were safe

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There were 139 calls by health professionals seeking expert advice on how to treat members of the public as the vaping habit rapidly spread

Further studies, particularly in primary human samples and additional in vivo models, are needed to strengthen the evidence and define the translational relevance of this pathway.