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Folic acid supplementation may reduce colorectal cancer risk in patients with inflammatory bowel disease: a systematic review and meta-analysis

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This process occurs via two primary pathways: clathrin-mediated endocytosis, where NPs are engulfed by clathrin-coated pits, and caveolae-mediated endocytosis, which involves small membrane invaginations called caveolae that facilitate NP internalization (79)

Strength of evidence was rated on a scale from -2 (very weak/no evidence) to +2 (very strong evidence) based on study methods, results, and limitations