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Goros RA, Xu X, Li G, Zuo YY (2023) Adverse biophysical impact of e-cigarette flavors on pulmonary surfactant

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European Journal of Endocrinology 167:1-10), 2012

More broadly, systematic multigenerational studies will be required to assess the stability, inheritance, and expression dynamics of R2-mediated insertions and to define genomic contexts that support durable Pol II-driven transgene expression

In short, if its something you need to expel from your mouth, dont use it