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Unlike PROTACs, which rely on bifunctional molecules to recruit E3 ubiquitin ligases, molecular glues are typically small molecules that induce or stabilize interactions between target proteins and ubiquitin ligases, thereby promoting selective protein degradation through the ubiquitin-proteasome system

A piece of strong mechanistic evidence revealed that withaferin A inhibits the chaperone activity of Prx1 and reduces the infection-induced TLR4 expression in macrophages (Noh et al., 2016) (Zhao Q

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There are many variables to chemotherapy: More than 100 different drugs are used in chemotherapy

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