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SHP type-1 (SHP-1) is involved in inducing apoptosis by increasing pro-apoptotic proteins such as the p53-Bax-caspase-3 pathway and by increasing JNK expression resulting in inhibition of anti-apoptotic proteins (Fig

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5 Overview of different long-chain fatty acid oxidation disorders 5.1 Disorders of carnitine transport 5.1.1 Primary carnitine deficiency / organic cation transporter 2 (OCTN2) deficiency / carnitine transporter disorder (CTD) Clinical presentation Patients with systemic primary carnitine deficiency (also known as OCTN2 deficiency or CTD

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Tip: For best results, apply to damp skin and allow to absorb before applying other products