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Given that it would be highly unethical to ask women to smoke or not to smoke during pregnancy, it is nearly impossible to remove the possibility that other variables might cause the negative outcomes associated with PCSE

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The increasing evidence supports that cytokines and primed immune cells from the gut-associated Peyers patches might be transported to the skin through microcirculation, which regulates the immune status and destroys the epithelial barrier of the skin (Sznt et al., 2019)