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the drug was discontinued in 3.6% of the persons in the CagriSema arm compared to 1.3% in the comparators' arms, and observed gastrointestinal adverse events per patient per year were 2.8 with CagriSema versus 2.6 with semaglutide 2.4 mg monotherapy [125]

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Interestingly, in LIRKO mice, Cyp7a1 expression was also markedly decreased, suggesting that insulin signaling is involved in Cyp7a1 expression 23

Sleep quality and the treatment of intestinal microbiota imbalance in chronic fatigue syndrome: a pilot study