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Before the development of the cigarette-manufacturing machine, smokers rolled their own or, more commonly in Ottoman lands, smoked tobacco in long-shafted pipes called ibuk (chee-BOOK) or ubuk (choo-BOOK, "stick")

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Current cigarette smoking and direct tubular injury Chronic smoking-induced damage to the renal proximal tubular epithelium has been studied with urinary enzymes as potential biomarkers of tubular toxicity