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Intraocular Pressure Measuring Intraocular pressure was measured using a calibrated applanation tonometer Tonopen XL by Reichert Technologies (the transducer was placed on the same spot of the cornea for each measurement)

Data analysis indicated significant differences in the metabolites between the Gly and negative control groups (Figure S1D, E), and the differences in amino acid and lipid metabolism were the most significant

Also in this setting, the potency of FOXO4-DRI was more pronounced when applied in consecutive rounds Not only did FOXO4-DRI selectively target the senescent cells, but it was also effective agains the induced chemo-toxicity observed in the form of liver toxicity and body weight loss

We then tested whether other agents that specifically caused nucleotide imbalance (rather than the DNA-driven and RNA-driven effects of 5FU) have the same mechanism of action

S4A and(Demaria et al., 2014))