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Even if these measures aimed at curbing the tobacco industrys use of the package as a promotional mini-billboard have yet to achieve the drop in cigarette consumption that proponents had hoped for, plain packaging has thrown a wrench into business-as-usual and has irritated libertarian ideologues

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Nicotine exposure via nAChRs can also cause -cell dysfunction, increasing -cell apoptosis, mitochondrial dysfunction, oxidative stress, inflammation, and eventually loss of -cell mass (22)

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