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Pravastatin the most hydrophilic drug is relatively soluble in water and methanol [38]

Consequently, this design aggravates the redox imbalance, causing a rapid increase in ROS in the short term in vitro, ultimately leading to the downstream signaling pathway activation and apoptosis of AML cells

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Continued innovation in ligand engineering, formulation optimization, and tumor microenvironment modulation is essential to enhance their translational success