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Encapsulation efficiency was measured using ICP-MS and revealed excellent encapsulation efficiency of DDA-GSH-AuNCs into PLGA matrix (93.09 1.71%), owing to the hydrophobic character of the nanoclusters that prevents its partition into the external polar phase (ethanol) and rather get encapsulated in the hydrophobic PLGA matrix

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Tendency of encapsulated AuNCs to leach out from the PLGA hosts was evaluated as a function of incubation time using ICP-MS